HtrA2/Omi protein (His tag) (80R-1010)
Purified recombinant Human HtrA2/Omi protein
|Synonyms||HtrA2/Omi protein, HtrA2 protein, HtrA/Omi -2, Serine protease 25 protein, HtrA/Omi -2 protein, OMI protein, High temperature requirement protein A2, HTRA2 protein, Omi stress-regulated endoprotease protein, PRSS25 protein, High temperature requirement protein A2 protein, Serine proteinase OMI protein, EC 188.8.131.52 protein, Serine protease HTRA2 protein, mitochondrial protein, HtrA/Omi 2 protein, HtrA/Omi 2, HtrA2/Omi|
Coomassie Blue stained SDS-PAGE of HtrA2/Omi protein (His tag) (80R-1010)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||134-458 amino acids: MAVPSPPPAS PPSQYNFIAD VVEKTAPAVV YIEILDRHPF LGREVPISNG SGFVVAADGL IVTNAHVVAD RRRVRVRLLS GDTYEAVVTA VDPVADIATL RIQTKEPLPT LPLGRSADVR QGEFVVAMGS PFALQNTITS GIVSSAQRPA RDLGLPQTNV EYIQTDAAID FGNAGGPLVN LDGEVIGVNT MKVTAGISFA IPSDRLREFL HRGEKKNSSS GISGSQRRYI GVMMLTLSPS ILAELQLREP SFPDVQHGVL IHKVILGSPA HRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR TQSQLAVQIR RGRETLTLYV TPEVTEGSHH HHHH|
|Grade & Purity||> 95% pure|
|Molecular Weight||36 kDa (334aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 50mM NaCl, 1 mM DTT, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HtrA2/Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death. Mature form of HtrA2/Omi (residues 134-458) was overexpressed in E. coli, and purified by conventional column chromatography techniques.|
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