Human CD27 ELISA kit (55R-2259)
ELISA kit for detection of CD27 (TNFRSF7) in the research laboratory
Overview
Overview
| Synonyms | Human TNFRSF7 ELISA kit |
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| Specificity | Human |
| Applications | ELISA |
| Assay Information | Sensitivity: 62.5 pg/ml-4000 pg/ml Sample types: Cell culture supernatants and serum |
Specifications
| Grade & Purity | ELISA grade |
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| Form & Buffer | Kit contents:Lyophilized recombinant human CD27 standard, 96-well plate precoated with anti-human CD27 antibody, sample diluent buffer, Biotinylated anti-human CD27 antibody, antibody diluent buffer,ABC Complexand diluent buffer, TMB color developing agen |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
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Storage & Safety
| Storage | Store at 4 deg Cshort term (6 months); -20 deg Cfor long term. Avoid multiple freeze-thaw cycles |
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General Information
| Biological Significance | CD27 (also called TNFRSF7) is a tumor necrosis factor receptor. This gene is mapped to 12p13.31. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein(SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |
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