HUS1 antibody (70R-13566)

Affinity purified Rabbit polyclonal HUS1 antibody

Synonyms Polyclonal HUS1 antibody, Anti-HUS1 antibody, HUS 1 antibody, HUS1, HUS1 antibody, HUS 1, HUS1 checkpoint homolog (S. pombe) antibody, HUS-1, hHUS1 antibody, hus1+-like protein antibody, checkpoint protein HUS1 antibody, HUS-1 antibody
Cross Reactivity Human
Applications IHC-P, WB

Images

Immunohistochemical staining using HUS1 antibody (70R-13566)

Immunohistochemical staining of paraffin-embedded CA922 xenograft using HUS1 antibody at a dilution of 1:500

Specifications

Host Rabbit
Isotype IgG
Method of Purification HUS1 antibody was purified by antigen-affinity chromatography
Molecular Weight 32 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 0.71 mg/ml

Usage & Assay Information

Usage Recommendations IHC-P: 1:100-1:500, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C, which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using HUS1 antibody (70R-13566)</font></div>     | Immunohistochemical staining of paraffin-embedded CA922 xenograft using HUS1 antibody at a dilution of 1:500
  • <div><font face=Calibri size=2>Western blot analysis using HUS1 antibody (70R-13566)</font></div>     | Western blot analysis of 30 ug of whole cell lysate (A: 293T) using a 12 % SDS PAGE gel and HUS1 antibody at a dilution of 1:1000

Availability: In stock

Price: €323.11
Size: 100 ul
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