IARS protein (His tag) (80-1377)
Purified recombinant IARS (OJ) protein (His tag)
Overview
Overview
| Synonyms | Isoleucyl-TRNA Synthetase protein, IleRS protein, OJ protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | 1-1262 aa |
|---|---|
| Expression System | Baculovirus |
| Grade & Purity | > 75% pure |
| Method of Purification | Purified using proprietary chromatographic techniques |
| Molecular Weight | 148 kDa |
| Tag/Conjugate | His-GST tag |
| Form & Buffer | Supplied in 50mM Tris buffer, pH 8.0, 150mM NaCl, 10% glycerol, 2mM MgCl2, 1mM EDTA and 2mM DTT |
Storage & Safety
| Storage | Ships on dry ice. Upon receipt, aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
General Information
| Biological Significance | IARS belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. |
|---|---|
| Expression | IARS is expressed in response to inflammation and DNA damage. IARS is expressed in the membrane and cytoplasm of the majority of mammalian cells. |
| Implications in Disease | Diseases associated with IARS include polymyositis, a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis, and dermatomyositis, a connective-tissue disease related to polymyositis (PM) that is characterized by inflammation of the muscles and the skin. |
| Post-Translational Modifications | Ubiquitination occurs at Lys410, Lys450, Lys868, Lys917 and Lys1051. |
| Database Links | Entrez Gene: 3376 Human, Omim: 600709 Human, SwissProt: P41252 Human |
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product