ICOS antibody (10R-6685)

Rat monoclonal ICOS antibody

Synonyms Monoclonal ICOS antibody, Anti-ICOS antibody
Specificity Mouse
Applications Functional Assay
Assay Information The ED50 of this protein, as measured by IL-6 induction in M1 cells, is 5-15 ng/ml in the presence of 1 ng/ml Mouse LIF Recombinant Protein. This corresponds to a specific activity of 2 x 105 - 6.7 x 104 Units/mg.

Images

Flow Cytometric analysis using ICOS antibody (10R-6685)

Staining of unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.06 ug of Rat IgG2b Isotype Control (open histogram) or 0.06 ug of CD278 antibody (filled histogram) followed by Anti-Rat IgG (biotin) and Streptavidin (PE). Total viable cells were used for analysis.

Specifications

Host Rat
Clone 7E.17G9
Isotype IgG2b kappa
Method of Purification ICOS antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The 7E.17G9 monoclonal antibody reacts with mouse ICOS, a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells.

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Images

  • Flow Cytometric analysis using ICOS antibody (10R-6685) | Staining of unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.06 ug of Rat IgG2b Isotype Control (open histogram) or 0.06 ug of CD278 antibody (filled histogram) followed by Anti-Rat IgG (biotin) and Streptavidin (PE). Total viable cells were used for analysis.

Availability: In stock

Price: €102.25
Size: 50 ug
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