ICOS antibody (10R-6685)
Rat monoclonal ICOS antibody
Overview
Overview
| Synonyms | Monoclonal ICOS antibody, Anti-ICOS antibody |
|---|---|
| Specificity | Mouse |
| Applications | Functional Assay |
| Assay Information | The ED50 of this protein, as measured by IL-6 induction in M1 cells, is 5-15 ng/ml in the presence of 1 ng/ml Mouse LIF Recombinant Protein. This corresponds to a specific activity of 2 x 105 - 6.7 x 104 Units/mg. |
Images
Flow Cytometric analysis using ICOS antibody (10R-6685)
Staining of unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.06 ug of Rat IgG2b Isotype Control (open histogram) or 0.06 ug of CD278 antibody (filled histogram) followed by Anti-Rat IgG (biotin) and Streptavidin (PE). Total viable cells were used for analysis.
Specifications
| Host | Rat |
|---|---|
| Clone | 7E.17G9 |
| Isotype | IgG2b kappa |
| Method of Purification | ICOS antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The 7E.17G9 monoclonal antibody reacts with mouse ICOS, a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells. |
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