IFNa2 protein (Mouse) (30R-2184)
Purified recombinant Mouse IFNa2 protein
Overview
Overview
| Synonyms | IFNa-2 protein, IFNa 2 protein, IFNa2, IFN-a2 protein, IFNa-2, IFNa 2, Interferon- alpha 2 protein |
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| Specificity | Mouse |
| Species | Mouse |
| Protein Type | Recombinant |
| Applications | ELISA |
| Assay Information |
Specifications
| Expression System | E.coli |
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| Grade & Purity | > 98% pure |
| Method of Purification | IFNa2 protein was purified by affinity chromatography. |
| Molecular Weight | 18 kDa |
| Form & Buffer | Supplied as a sterile liquid with 50mM NaAc, 0.1M NaCl, 0.5%BSA, pH 5.0 |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Bioactivity | The recombinant mouse IFN- alpha2 has been tested for inhibition of the cytopathic effect of EMC virus onL929 cells. The ED50 for this effect is typically 0.1 ng/ml, corresponding to a specific activity of 1 x 107 U/mg. |
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Storage & Safety
| Storage | Store at -70 deg C or less. |
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| Endotoxin Levels | Less than 0.01 ng/ug cytokine as determined by the LAL assay. |
General Information
| Biological Significance | IFN- alpha 2 is a type I interferon, previously known as B-cell interferon, leukocyte interferon, lymphoblast interferon, and pH2-stable interferon. IFN- alpha 2 is one of at least 23 different known variants of IFN- alpha. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. IFN- alpha forms are produced by monocytes/macrophages, lymphoblastoid cells, fibroblasts, and a number of different cell types following induction by viruses, nucleic acids, glucocorticoid hormones, and low-molecular weight substances. IFN- alpha 2 demonstrates antiviral, antiparasitic, antiproliferative activities. |
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