IFNL3 protein (80R-4218)
Recombinant Human IFNL3 protein with His tag
Overview
Overview
| Synonyms | Human IFNL3 protein, Recombinant IFNL3 protein, Interferon lambda-3 protein, IL-28B protein, IL28B protein, IL28C protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | Control, SDS-PAGE |
Images
Coomassie blue stained SDS-PAGE showing analysis of IFNL3 protein(80R-4218)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 22-196 amino acids of Human IFNL3 protein: VPVARLRGAL PDARGCHIAQ FKSLSPQELQ AFKRAKDALE ESLLLKDCKC RSRLFPRTWD LRQLQVRERP VALEAELALT LKVLEATADT DPALGDVLDQ PLHTLHHILS QLRACIQPQP TAGPRTRGRL HHWLHRLQEA PKKESPGCLE ASVTFNLFRL LTRDLNCVAS GDLCVHHHHH H |
|---|---|
| Expression System | Insect cells |
| Grade & Purity | > 85% pure |
| Molecular Weight | 20.4 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid in PBS (pH 7.4) containing 20% glycerol, 1mM EDTA, 0.1mM PMSF |
| Concentration | 250 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term. For long term storage, aliquot and store at -20 deg C. Avoid repeated freeze thaw cycles. |
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| Endotoxin Levels | LAL method determined levels of < 1.0 EU/ug of protein |
General Information
| Biological Significance | IFNL3, also known as Interferon lambda-3, is a secreted protein which belongs to the IL-28/IL-29 family. It is a cytokine with immunomodulatory activity. It up-regulates MHC class I antigen expression. This protein displays potent antiviral activity and antitumor activity. It seems to signal through the Jak-STAT pathway. It also contributes to viral resistance and is known to be upregulated by interferons and by RNA virus infection. Recombinant human IFNL3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
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