IGFBP1 protein (30R-2384)

Purified recombinant Human IGFBP1 protein

Synonyms PP12 protein, hIGFBP-1 protein, IGFBP 1 protein, IGFBP1, IGFBP-1 protein, AFBP protein, IGFBP 1, IBP-1 protein, IGFBP-1 protein, IGF-Binding Protein 1 protein, IGF-BP25 protein, IGFBP-1
Species Human
Protein Type Recombinant

Specifications

Expression System NSO cells
Grade & Purity > 98% pure
Method of Purification IGFBP1 protein was purified using a a proprietary chromatographic technique.
Molecular Weight 28.8 kDa
Form & Buffer Sterile filtered and lyophilized from 10 mM HCl

Usage & Assay Information

Bioactivity The ED50 as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels <0.1 ng/ug

General Information

Biological Significance IGFBP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, decidual, and kidneys and is the most abundant IGF BP in amniotic fluid. Levels of IGF BP1 in serum are lowest after food. IGF BP1 binds both IGF I and IGF II with equal affinity. Phosphorylated IGF BP1 hinders IGF actions, whereas nonphosphorylated IGF BP1 is stimulatory.

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