IGLL1 protein (His tag) (80R-2702)
Purified recombinant IGLL1 protein (His tag)
|Synonyms||Immunoglobulin lambda-like polypeptide 1 protein, 14.1 protein, AGM2 protein, CD179b protein, IGL1 protein, IGL5 protein, IGLJ14.1 protein, IGLL protein, IGO protein, IGVPB protein, VPREB2 protein, IGLL1, IGLL 1, IGLL-1, IGLL 1 protein, IGLL-1 protein|
SDS-PAGE analysis of IGLL1 protein (His tag) (80R-2702)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||38-213 aa: MGSSHHHHHH SSGLVPRGSH MGSLLRPTAA SQSRALGPGA PGGSSRSSLR SRWGRFLLQR GSWTGPRCWP RGFQSKHNSV THVFGSGTQL TVLSQPKATP SVTLFPPSSE ELQANKATLV CLMNDFYPGI LTVTWKADGT PITQGVEMTT PSKQSNNKYA ASSYLSLTPE QWRSRRSYSC QVMHEGSTVE KTVAPAECS|
|Grade & Purity||> 85% pure|
|Molecular Weight||21.5 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol|
Storage & Safety
|Storage||Can be stored at 4 deg C for short terms (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles|
|Biological Significance||The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. IGLL1 is one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. Recombinant human IGLL1protein, fused to His-tag at N-terminus, was expressed in E.coli.|
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