IL1 alpha protein (Mouse) (30R-AI002)
Purified recombinant Mouse IL1 alpha protein
Overview
Overview
| Synonyms | Hematopoietin-1 protein, IL 1 protein, MCF protein, LAF protein, Lymphocyte-activating factor protein, IL 1, Leukocyte Endogenous Mediator protein, IL-1 alpha protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, Interleukin 1 alpha protein, LEM protein, EP protein, IL1, IL-1 protein, IL-1 |
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| Species | Mouse |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of IL1 alpha protein corresponding to amino acids SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS. |
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| Expression System | E.coli |
| Grade & Purity | > 98% pure |
| Molecular Weight | 17.9 kDa |
| Form & Buffer | Lyophilized from 5mM tris, pH 8.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. |
Usage & Assay Information
| Bioactivity | The ED50 as determined by the dose-dependent stimulation of Mouse D10S cells is 5 x 10^8 units/mg. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine. |
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