IL1 alpha protein (Mouse) (30R-AI002)

Purified recombinant Mouse IL1 alpha protein

Synonyms Hematopoietin-1 protein, IL 1 protein, MCF protein, LAF protein, Lymphocyte-activating factor protein, IL 1, Leukocyte Endogenous Mediator protein, IL-1 alpha protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, Interleukin 1 alpha protein, LEM protein, EP protein, IL1, IL-1 protein, IL-1
Species Mouse
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL1 alpha protein corresponding to amino acids SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 17.9 kDa
Form & Buffer Lyophilized from 5mM tris, pH 8.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent stimulation of Mouse D10S cells is 5 x 10^8 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine.

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Availability: In stock

Price: €224.95
Size: 10 ug
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