IL1 beta protein (30R-2480)

Purified recombinant Rat IL1 beta protein

Synonyms IL beta-1 protein, Mononuclear Cell Factor (MCF) protein, IL beta 1, Lymphocyte-activating factor (LAF) protein, Endogenous Pyrogen (EP) protein, IL beta-1, IL1 beta, IL beta 1 protein, Leukocyte Endogenous Mediator (LEM) protein, Catabolin protein
Species Rat
Protein Type Recombinant

Specifications

Expression System E.coli
Grade & Purity > 98% pure
Method of Purification IL1 beta protein was purified using a a proprietary chromatographic technique.
Molecular Weight 17.3 kDa
Form & Buffer Sterile filtered and lyophilized from 10 mM Sodium Acetate, pH 6.5

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.01 ng/ml, corresponding to a specific activity of > 1 x 10^7 units/mg

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels <0.1 ng/ug

General Information

Biological Significance IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1 beta binds to the same receptor and has similar biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGFlike activity and stimulation of the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.

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