IL10 protein (30R-AI075)
Purified recombinantRat IL10 protein
Overview
Overview
| Synonyms | CSIF protein, B-TCGF protein, TGIF protein, IL 10 protein, Interleukin 10 protein, IL-10 protein, IL10, IL 10, IL-10 protein, IL-10 |
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| Cross Reactivity | Cross reacts with mouse, rat. |
| Species | Rat |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of IL10 protein corresponding to amino acids SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN |
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| Expression System | E.coli |
| Grade & Purity | > 98% pure |
| Molecular Weight | 18.7 kDa |
| Form & Buffer | Lyophilized from 20mM Na3PO4, pH 7.0. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml. |
Usage & Assay Information
| Bioactivity | The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is less than 10ng/ml. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-a. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Rat IL-10 is an 18.7 kDa protein of 160 amino acid residues. |
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