IL10RA protein (10R-11304)

Recombinant Human IL10RA protein with His tag

Synonyms Human IL10RA protein, Recombinant IL10RA protein, Interleukin-10 receptor subunit alpha protein, CD210 protein, CD210a protein, CDW210A protein, HIL-10R protein, IL-10R1 protein, IL10R protein
Species Human
Protein Type Recombinant
Applications Control, SDS-PAGE

Images

Coomassie blue stained SDS-PAGE showing analysis of IL10RA protein(80R-4212)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 22-235 amino acids of Human IL10RA protein: HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS LLTSGEVGEF CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH
Expression System Insect cells
Grade & Purity > 85% pure
Molecular Weight 25.2 kDa
Tag/Conjugate His tag
Form & Buffer Supplied as liquid in PBS (pH 7.4) containing 10% glycerol
Concentration 200 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term. For long term storage, aliquot and store at -20 deg C. Avoid repeated freeze thaw cycles.
Endotoxin Levels LAL method determined levels of < 1.0 EU/ug of protein

General Information

Biological Significance IL10RA, also known as Interleukin-10 receptor subunit alpha, is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. It has been shown to interact with Interleukin 10 and Janus kinase 1. Recombinant human IL10RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

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Images

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Coomassie blue stained SDS-PAGE showing analysis of IL10RA protein(80R-4212)



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Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €241.31
Size: 100 ul
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