IL10RA protein (10R-11304)
Recombinant Human IL10RA protein with His tag
Overview
Overview
| Synonyms | Human IL10RA protein, Recombinant IL10RA protein, Interleukin-10 receptor subunit alpha protein, CD210 protein, CD210a protein, CDW210A protein, HIL-10R protein, IL-10R1 protein, IL10R protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | Control, SDS-PAGE |
Images
Coomassie blue stained SDS-PAGE showing analysis of IL10RA protein(80R-4212)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 22-235 amino acids of Human IL10RA protein: HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS LLTSGEVGEF CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH |
|---|---|
| Expression System | Insect cells |
| Grade & Purity | > 85% pure |
| Molecular Weight | 25.2 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid in PBS (pH 7.4) containing 10% glycerol |
| Concentration | 200 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term. For long term storage, aliquot and store at -20 deg C. Avoid repeated freeze thaw cycles. |
|---|---|
| Endotoxin Levels | LAL method determined levels of < 1.0 EU/ug of protein |
General Information
| Biological Significance | IL10RA, also known as Interleukin-10 receptor subunit alpha, is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. It has been shown to interact with Interleukin 10 and Janus kinase 1. Recombinant human IL10RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
|---|
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product