IL11 protein (Mouse) (30R-AI131)
Purified recombinant Mouse IL11 protein
Overview
Overview
| Synonyms | Interleukin 11 protein, AGIF protein, IL 11 protein, IL-11 protein, IL-11 protein, IL11, IL-11, Adipogenesis inhibitory factor protein, IL 11 |
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| Species | Mouse |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of IL11 protein corresponding to amino acids MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL. |
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| Expression System | E.coli |
| Grade & Purity | > 98% pure |
| Molecular Weight | 19.1 kDa |
| Form & Buffer | Supplied as a lyophilized powder. |
Usage & Assay Information
| Bioactivity | The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse T11 cells is approximately 2.0 ng/ml, corresponding to a specific activity of approximately 5 x 10^5 units/mg. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | IL11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. |
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