IL12 p80 protein (30R-AI133H)
Recombinant Human IL12 p80 protein
Overview
Overview
| Synonyms | Human IL12 p80 antigen, IL-12, IL-12 protein, Interleukin 12 protein, IL12, IL 12, TSF protein, Cytotoxic lymphocyte maturation factor protein, CTL maturation factor protein, TCMF protein, IL-12 protein, CLMF protein, IL 12 protein, NKSF protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Expression System | Hi-5 cells |
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| Grade & Purity | > 95% pure |
| Molecular Weight | 80 kDa |
| Form & Buffer | Supplied as lyophilized from 10 mM Sodium Acetate - pH 5.6, 90 mM NaCl, 2% Sucrose and 4.0% Mannitol and sterile filtered through a 0.2 micron filter. Reconstitute in sterile water to a concentration of 1 mg/ml. Do not vortex. |
Storage & Safety
| Storage | Store at 4 deg Cfor up to 1 week. Forlong termstorage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in aliquots at -20/-70 deg C. Avoid repeated freeze thawing. |
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General Information
| Biological Significance | IL12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. |
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| Implications in Disease | Elevated levels of IL12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. |
| Sequence Information | Human IL12 p80 is disulfide linked homodimer consisting of two p40 chains of IL12. Amino acid sequence as follows: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW TPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS |
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