IL12 protein (30R-2252)

Purified recombinant Human IL12 protein

Synonyms IL 12 protein, IL12, Interleukin-12 protein, IL-12 protein, p70 protein, IL 12, IL-12, IL12 protein
Specificity Mouse
Species Human
Protein Type Recombinant
Applications FC
Assay Information The pre-titrated test size contains 0.2% BSA.

Specifications

Expression System Insect cells
Grade & Purity > 98% pure
Molecular Weight 57 kDa
Form & Buffer Supplied as a sterile liquid with 20 mM NaH2PO4, pH 6.0, 0.2 MNaCl. 0.22 um filtered.
Concentration 5 ul (1 ug)/test

Usage & Assay Information

Usage Recommendations FC: 5 ul (1 ug)/test per million cells (100 ul blood)
Bioactivity Testing in progress.

Storage & Safety

Storage Store at -70 deg C or less.
Endotoxin Levels Less than 0.01 ng/ug cytokine as determined by the LAL assay.

General Information

Biological Significance Interleukin-12 is a heterodimeric 70 kD cytokine composed of two covalently linked, glycosylated chains, 40kD and 35-kD. IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides, to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. It is now established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-gamma and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation.

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Availability: In stock

Price: €1,631.90
Size: 100 ug
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