IL12 protein (30R-2509)
Purified recombinant Rat IL12 protein
Overview
Overview
| Synonyms | TSF protein, IL 12, Cytotoxic lymphocyte maturation factor (CLMF) protein, NKSF protein, CTL maturation factor (TCMF) protein, Edodekin-alpha protein, IL-12 protein, IL-12 protein, IL-12, IL12, IL 12 protein |
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| Species | Rat |
| Protein Type | Recombinant |
Specifications
| Expression System | Sf-9 insect cells |
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| Grade & Purity | > 95% pure |
| Method of Purification | IL12 protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 70 kDa |
| Form & Buffer | Supplied in lyophilized form from 1 mg/ml solution with no additives |
Usage & Assay Information
| Bioactivity | The ED50 range is 001-0.005 ng/ml, as determined by the dose-dependent secretion of IFN-gamma from PHA and IL-12 activated mouse splenocytes that has been co-stimulated with PMA |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | <0.1 ng/ug |
General Information
| Biological Significance | IL-12 is a potent regulator of cell mediated immune responses and in induces IFN gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN gamma producing Th1 cells. |
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