IL12 protein (Mouse) (30R-AI007)
Purified recombinant Mouse IL12 protein
Overview
Overview
| Synonyms | TCMF protein, CTL maturation factor protein, IL12, TSF protein, IL-12 protein, Interleukin 12 protein, IL-12, IL 12 protein, IL-12 protein, CLMF protein, IL 12, NKSF protein, Cytotoxic lymphocyte maturation factor protein |
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| Species | Mouse |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of IL12 protein corresponding to amino acids RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV VTINRVMGYL SSA. |
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| Expression System | CHO cells |
| Grade & Purity | > 98% pure |
| Molecular Weight | 75 kDa |
| Form & Buffer | Lyophilized from PBS, pH 7.2, sterile filtered. Reconstitute in PBS to a concentration 0.1 - 1.0 mg/ml. |
Usage & Assay Information
| Bioactivity | Determined by its ability to induce cell proliferation in T-cell enriched PBMCs. The expected ED50 is = 0.1 ng/ml, corresponding to a specific activity of = 1 x 10^7 units/mg. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | IL12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. |
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