Monoclonal IL13 antibody, Anti-IL13 antibody, IL13 antibody, IL 13, IL-13 antibody, Interleukin-13 antibody, IL 13 antibody, IL13, IL-13
Specificity
Mouse
Applications
FC
Assay Information
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Store at 2-8 deg C. Do not freeze. Protect from light.
General Information
Biological Significance
The 1316H antibody reacts with mouse IL-13. The 1316H antibody is a neutralizing antibody. Mouse interleukin-13, originally designated p600, is a 11.6 kDa protein secreted by activated T helper cells, CD8+ T cells, and NK cells. IL-13 was originally identified in 1989 through differential hybridization of cDNA libraries prepared from T helper 1 and T helper 2 cells. IL-13 contains four cysteine residues, which form two intramolecular disulfide bonds. IL-13 shares many activities with IL-4 this relates to a requirement for IL-4R alpha chain for signal transduction. The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression, and suppression of inflammatory cytokine expression. IL-13 induces CD23 expression on B cells and enhances CD72, and expression of class II MHC gene products. Mouse IL-13 does not display the activities on T cells and B cell stimulatory effects which IL-4 exhibits. Mouse IL-13 is active on human and mouse cells.