IL13 protein (30R-AI135)

Purified recombinant Human IL13 protein

Synonyms IL13, IL 13, IL-13, Interleukin 13 protein, Human P600 protein, IL 13 protein, Mouse protein, IL-13 protein, NC300 protein, IL-13 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL13 protein corresponding to amino acids VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSIVWSVDI TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 11.9 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is 2.5 x 10^4 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL13 in mice resulted in impaired Th2 cell development and indicated an important role for IL13 in the expulsion of gastrointestinal parasites. IL13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL1beta, TNF-alpha, IL6 and IL8. IL13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL13 activity inhibits the pathophysiology of asthma.

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Availability: In stock

Price: €211.69
Size: 10 ug
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