IL18 antibody (70R-12292)

Rabbit polyclonal IL18 antibody

Synonyms Polyclonal IL18 antibody, anti-IL18 antibody, Interluekin 18 antibody, IL 18, IL18, IL-18 antibody, IL 18 antibody, IL-18, Interluekin-18 antibody, IL-18 antibody, IL 18 antibody
Cross Reactivity Mouse
Applications IP, Neutralization, WB
Immunogen IL18 antibody was raised in Rabbit using synthetic peptide of mouse IL-18 as the immunogen.

Specifications

Host Rabbit
Isotype IgG
Method of Purification IL18 antibody was purified by affinity chromatography
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IP: 2-5 ug/ml, Neutralization: 2-5 ug/ml, WB: 0.5-4 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance IL-18 is a novel proinflammatory cytokine that augments natural killer activity in spleen cells. It also has other biological properties such as activation of NF-kB, stimulation of Fas ligand expression, induction of CC and CXC chemokines. IL-18 increases production of competent HIV. IL-18 is related to the IL-1 family. One of the IL-18 receptor chains is the IL-1 receptor-related protein, a member of the IL-1R family. Like IL-1 beta, IL-18 is first synthesized as a leaderless precursor requiring the IL-1 beta converting enzyme for cleavage into an active molecule. IL-18 may play a role in tissue injury in inflammatory reactions.

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