IL2 protein (30R-2157)
Purified recombinant Human IL2 protein
Overview
Overview
| Synonyms | Interleukin 2 protein, TCGF protein, IL 2 protein, IL-2 protein, IL 2 protein, IL2, Interleukin-2 protein, IL-2, Aldesleukin protein, T-cell growth factor protein, IL-2 protein, IL 2 |
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| Specificity | Human |
| Species | Human |
| Protein Type | Recombinant |
| Applications | IHC, IP, WB |
| Assay Information | It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest |
Specifications
| Expression System | E.coli |
|---|---|
| Grade & Purity | > 98% pure |
| Method of Purification | IL2 protein was purified by affinity chromatography. |
| Form & Buffer | Supplied as a sterile liquid with 40mM Acetate, 0.2M NaCl, pH 5, 1.0% BSA. 0.22 um filtered. |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | WB: = 2 ug/ml |
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| Bioactivity | The ED50 of this protein, as measured by CTLL-2 proliferation assay, is less than or equal to 175pg/ml. This corresponds to a specific activity of greater than or equal to 5.7 x 10e6 Units/mg. |
Storage & Safety
| Storage | Store at -70 deg C or less. |
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| Endotoxin Levels | Less than 0.01 ng/ug cytokine as determined by the LAL assay. |
General Information
| Biological Significance | Human IL-2 is a ~15 kDa factor produced mainly by activated CD4 T cells. IL-2 induces cell cycle progression of resting cells in an antigen non-specific manner and allows clonal expansion of activated T cells. IL-2 also acts on activated B cells, monocytes, NK, LAK cells, and on oligodendroglial cells in vitro. In addition, IL-2 plays a role in hematopoiesis, tumor surveillance and anti-inflammatory reactions and hence is a central regulator of the immune response. Non-glycosylated IL-2 is biologically active. |
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