IL21 protein (Mouse) (30R-AI140)

Purified recombinant Mouse IL21 protein

Synonyms IL-21 protein, IL21, IL-21, IL-21 protein, IL 21 protein, Interleukin 21 protein, IL 21
Species Mouse
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL21 protein corresponding to amino acids MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 15 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Assay #1:-Measured by its ability to induce STAT3 signaling in U937 Stat3-Luc reporter cells.Assay #2:-Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected-ED50-is = 1.0 ng/ml, corresponding to a specific activity o

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL21 include induction of differentiation of T-cells-stimulated-B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL21 exerts its effect through binding to a specific type I cytokine receptor, IL21R, which also contains the gamma chain (?c) found in other cytokine receptors including IL2, IL4, IL7, IL9 and IL15.

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Availability: In stock

Price: €185.94
Size: 10 ug
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