IL21 protein (Mouse) (30R-AI140)
Purified recombinant Mouse IL21 protein
Overview
Overview
| Synonyms | IL-21 protein, IL21, IL-21, IL-21 protein, IL 21 protein, Interleukin 21 protein, IL 21 |
|---|---|
| Species | Mouse |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of IL21 protein corresponding to amino acids MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS. |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 98% pure |
| Molecular Weight | 15 kDa |
| Form & Buffer | Supplied as a lyophilized powder. |
Usage & Assay Information
| Bioactivity | Assay #1:-Measured by its ability to induce STAT3 signaling in U937 Stat3-Luc reporter cells.Assay #2:-Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected-ED50-is = 1.0 ng/ml, corresponding to a specific activity o |
|---|
Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|---|
| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | IL21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL21 include induction of differentiation of T-cells-stimulated-B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL21 exerts its effect through binding to a specific type I cytokine receptor, IL21R, which also contains the gamma chain (?c) found in other cytokine receptors including IL2, IL4, IL7, IL9 and IL15. |
|---|
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product