IL31 protein (30R-AI025)

Purified recombinant Human IL31 protein

Synonyms Interleukin 31 protein, IL 31, IL 31 protein, IL31, IL-31, IL-31 protein, IL-31 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL31 protein corresponding to amino acids SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 15.8 kDa
Form & Buffer Lyophilized from 10mM Na3PO4, pH 7.5. Reconstitute with distilled water to a concentration of 0.1 - 0.5 mg/ml.

Usage & Assay Information

Bioactivity Measured by its ability to induce STAT3 activation in human U87 cells.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Human IL31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.

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Availability: In stock

Price: €211.69
Size: 10 ug
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