IL32 protein (His tag) (80R-1113)
Purified recombinant Human IL32 protein
|Synonyms||Natural killer cells protein 4 protein, Interleukin 32 isoform A IL 32alpha protein, TAIFd protein, IL-32 protein, IL 32 protein, IL 32gamma protein, TAIFc protein, IL 32delta protein, IL 32beta protein, Tumor necrosis factor alpha-inducing factor (TAIF) protein, Interleukin 32 isoform A protein, TAIFa protein, IL32, Interleukin 32 protein, IL-32 protein, IL-32, IL 32, NK4 protein, TAIFb protein, TAIF protein, Interleukin 32 protein, il32, NK 4 protein, Natural killer cells protein 4(NK4) protein|
Coomassie Blue stained SDS-PAGE of IL32 protein (His tag) (80R-1113)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-131 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCF PKVLSDDMKK LKARMHQAIE RFYDKMQNAE SGRGQVMSSL AELEDDFKEG YLETVAAYYE EQHPELTPLL EKERDGLRCR GNRSPVPDVE DPATEEPGES FCDKSYGAPR GDKEELTPQK CSEPQSSK|
|Grade & Purity||> 95% pure|
|Molecular Weight||19.1 kDa (168aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Interleukin 32 isoform A belongs to cytokine family. This protein expression is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. It has the ability to induce proinflammatory cytokines such as TNFalpha and IL8 in THP1 cells, and activates typical cytokine signaling pathways involving NFkB and p38. IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton. Recombinant human Interleukin 32, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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