IL33 protein (30R-2529)

Purified recombinant Mouse IL33 protein

Synonyms NKHEV protein, Nuclear factor from high endothelial venules protein, DKFZp586H0523 protein, IL33, DVS27 protein, IL 33 protein, IL-1F11 protein, IL 33, IL-33, NFEHEV protein, IL-33 protein, RP11-575C202 protein, C9orf26 protein, NF-HEV protein, Interleukin-1 family member 11 protein, IL-33 protein, Interleukin 33 protein
Species Mouse
Protein Type Recombinant

Specifications

Expression System E.coli
Grade & Purity > 97% pure
Method of Purification IL33 protein was purified using a a proprietary chromatographic technique.
Molecular Weight 17.5 kDa
Form & Buffer Sterile filtered and lyophilized from 20 mM phosphate buffer, pH 7.4, 150 mM NaCl, 1 mM EDTA and 2 mM 2-ME.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is 0.05 ng/ml, corresponding to a specific activity of 2 x 10^6 units/mg

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels <0.1 ng/ug

General Information

Biological Significance Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. This cytokine was previously named NF-HEV 'nuclear factor in high endothelial venules' (HEVs) since it was originally identified in these specialized cells. IL-33 mediates its biological effects by interacting with the receptors ST2 and IL-1 Receptor Accessory Protein, activating intracellular molecules in the NF-?B and MAP kinase signaling pathways that drive production of type 2 cytokines from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.

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