IL33 protein (His tag) (80R-3995)
Recombinant Mouse IL33 protein
Overview
Overview
| Synonyms | Recombinant IL33 protein Interleukin-33 protein, 230117N10Rik protein, IL-33 protein, Il-33 protein, Il1f11 protein, Interleukin 33 protein |
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| Species | Mouse |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
Coomassie blue stained SDS-PAGE showing analysis of IL33 protein (His tag) (80R-3995)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 109-266 aa; MGSSHHHHHH SSGLVPRGSH MGSSIQGTSL LTQSPASLST YNDQSVSFVL ENGCYVINVD DSGKDQEQDQ VLLRYYESPC PASQSGDGVD GKKLMVNMSP IKDTDIWLHA NDKDYSVELQ RGDVSPPEQA FFVLHKKSSD FVSFECKNLP GTYIGVKDNQ LALVEEKDES CNNIMFKLSK I |
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| Expression System | E.coli |
| Grade & Purity | > 85% pure |
| Molecular Weight | 18.1 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid in PBS,10% glycerol, 1 mM DTT |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C for 1-2 weeks. For long term storage, aliquot and store at -20 to -70 deg C. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1. Recombinant mouse IL33 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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