IL4 protein (Mouse) (30R-AI079)

Purified recombinant Mouse IL4 protein

Synonyms Interleukin 4 protein, IL 4, IL 4 protein, IL-4, BCGF protein, B cell stimulating factor protein, BSF-1 protein, IL4, IL-4 protein, BCDF protein, IL-4 protein
Species Mouse
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL4 protein corresponding to amino acids MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 13.5 kDa
Form & Buffer Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent proliferation of Mouse HT-2 cells is 5 x 10^5 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL4, IL5, IL6, IL10, and IL13, which favor a humoral immune response. Another dominant function of IL4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL4 production by Th2 cells has been associated with elevated IgE production and allergy.

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