IL5 antibody (biotin) (61R-I126abt)

Rat monoclonal IL5 antibody (biotin)

Synonyms Monoclonal IL5 antibody, Anti-IL5 antibody, IL 5 antibody, IL-5 antibody, IL5, IL 5, IL-5
Specificity Human IL-5
Cross Reactivity To be determined by end-user
Applications ELISA
Immunogen IL5 antibody (biotin) was raised in rat using recombinant human IL-5 as the immunogen.

Specifications

Host Rat
Clone JES1-5A10
Isotype IgG2a
Tag/Conjugate Biotin
Form & Buffer Supplied as a liquid in PBS, with NaN3 added as preservative.
Concentration 0.5 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Interleukin 5 or IL-5 is an interleukin produced by T helper-2 cells and mast cells. Its functions are to stimulate B cell growth and increase immunoglobulin secretion. It is also a key mediator in eosinophil activation. IL-5 is a 115 amino acid (in man, 133 in the mouse) long TH2 cytokine which is part of the hematopoietic family. Unlike other members of this cytokine family (namely IL-3 and GM-CSF) , this glycoprotein in its active form is a homodimer. The IL-5 gene is located on chromosome 11 (in the mouse, chromosome 5 in humans) in close proximity to the genes encoding IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF) which are often co-expressed in TH2 cells. Interleukin-5 is also expressed by eosinophils and has been observed in the mast cells of asthmatic airways by immunohistochemistry. IL-5 expression is regulated by several transcription factors including GATA3.

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Availability: In stock

Price: €558.16
Size: 500 ug
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