IL6R alpha protein (30R-AI080)

Purified recombinant Human IL6R alpha protein

Synonyms B cell stimulatory factor-2 protein, soluble IL-6 receptor alpha protein, IL-6, IL6, Interleukin 6R alpha protein, CD126 protein, IL-6R alpha protein, IL-6 protein, IL 6 protein, IL 6
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL6R protein corresponding to amino acids LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD.
Expression System HEK cells
Grade & Purity > 98% pure
Molecular Weight 37.6 kDa
Form & Buffer Lyophilized from 1x PBS. Reconstitute in 1X PBS to a concentration of 0.1-1.0 mg/ml. When dissolved, dilute further into aqueous buffered solutions.

Usage & Assay Information

Bioactivity The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is approximately 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL6 mediates its biological effects through the type I IL6 receptor system that consists of two chains, IL6Ra and gp130. The IL6Ra chain is the binding component specific to IL6; while the gp130 only transmits signals of IL6 when bound to IL6Ra. The gp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL6 is composed of IL6Ra alone. IL6Ra is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL6Ra which consists of only the extracellular domain of the IL6Ra chain, acts as an agonist of IL6 activity at low concentrations.

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