Polyclonal Insulin R alpha antibody, Anti-Insulin R alpha antibody, Insulin Receptor alpha antibody
Applications
IHC-P, WB
Immunogen
Insulin R alpha antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human Insulin R alpha, identical to the related rat and Rabbit sequence as the immunogen
Optimal conditions to be determined by the end user
Storage & Safety
Storage
Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.
General Information
Biological Significance
Insulin receptor is a tetramer of 2 alpha and 2 beta subunits. The alpha and beta subunits are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin. The insulin receptor has an intrinsic tyrosine kinase activity that is essential for signal transduction. A mutant insulin receptor gene lacking almost the entire kinase domain has been identified in an individual with type A insulin resistance and acanthosis nigricans.