Insulin Receptor alpha antibody (10R-8655)
Mouse monoclonal Insulin Receptor alpha antibody
Overview
Overview
| Synonyms | Monocloclonal Insulin Receptor alpha antibody, HIR A antibody, INSR alpha antibody, INSR alpha antibody, INSR antibody, Insulin receptor antibody, Insulin receptor subunit alpha antibody, IR antibody, Insulin Receptor alpha, Anti-Insulin Receptor alpha antibody, CD220 antibody, CD220 antigen antibody, HHF5 antibody |
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| Specificity | Alpha subunit of human insulin receptor |
| Cross Reactivity | Human |
| Applications | ELISA, IP, Neutralization, WB |
| Immunogen | Insulin Receptor alpha antibody was raised in Mouse using highly purified insulin receptors (alpha-subunit) from human term placentas as the immunogen |
Specifications
| Host | Mouse |
|---|---|
| Clone | MA-20 |
| Isotype | IgG2b |
| Method of Purification | Insulin Receptor alpha antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in 10 mM phosphate buffer (pH 7.4), 100 mM NaCl, and 0.1% sodium azide |
Storage & Safety
| Storage | Store at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | INSR binds insulin and has a tyrosine protein kinase activity. The short isoform has a higher affinity for insulin. The receptor mediates the metabolic functions of insulin. The receptor binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Defects in INSR are the cause of insulin resistance. |
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