IP10 protein (30R-2227)
Purified recombinant Human IP10 protein
Overview
Overview
| Synonyms | IP 10, IP-10, IP10, IP 10 protein, IP-10 protein, IP10 protein |
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| Specificity | Mouse |
| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
| Assay Information | Currently there is no reliable bioassay available for recombinant mouse IL-17B. |
Specifications
| Expression System | E.coli |
|---|---|
| Grade & Purity | > 97% pure |
| Method of Purification | IP10 protein was purified by affinity chromatography. |
| Molecular Weight | 8.8 kDa |
| Form & Buffer | Supplied as a sterile liquid with phosphate buffered saline, 1 % BSA, pH 7.2 |
Usage & Assay Information
| Bioactivity | The bioactivity of this protein was determined by transmigration assay of human T lymphocytes, with maximum chemotaxis observed at 100-200 ng/ml. |
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Storage & Safety
| Storage | Store at -70 deg C or less. |
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| Endotoxin Levels | Less than 0.01 ng/ug cytokine as determined by the LAL assay. |
General Information
| Biological Significance | IP-10, or Interferon Gamma Inducible Protein 10, is a CXC chemokine also known as CXCL10. IP-10 is induced in monocytes, fibroblasts, and endothelial cells by IFNgamma. It is also induced by LPS, IL-1beta, TNF- alpha, IL-12, and viral infection. IP-10 is a chemoattractant for CXCR3+ T cells, which plays an important role in Th1-type inflammatory diseases, as well as several endocrine-related autoimmune diseases such as Hashimoto's thyroiditis. Recombinant human IP-10 produced in E.Coli is a single, non-glycosylated polypeptide containing 77 amino acids and with a molecular mass of 8.5 kDa. |
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