JNK1 antibody (70R-12562)

Affinity purified Rabbit polyclonal JNK1 antibody

Synonyms Polyclonal JNK1 antibody, Anti-JNK1 antibody, JNK21B1/2 antibody, SAPK1 antibody, c-Jun N-terminal kinase 1 antibody, JNK1, JUN N-terminal kinase antibody, JNK-1 antibody, mitogen-activated protein kinase 8 isoform JNK1 alpha1 antibody, MAP kinase 8 antibody, PRKM8 antibody, JNK 1, JNK antibody, JNK-1, mitogen-activated protein kinase 8 isoform JNK1 beta2 antibody, JNK1 antibody, stress-activated protein kinase 1c antibody, stress-activated protein kinase 1 antibody, JNK1A2 antibody, JNK 1 antibody, MAPK8 antibody, mitogen-activated protein kinase 8 antibody
Cross Reactivity Human, Mouse
Applications ICC, IF, WB
Immunogen JNK1 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 5 and 300 of JNK1

Images

Western blot analysis using JNK1 antibody (70R-12562)

Western blot analysis of 50 ug of whole cell lysate (A: Mouse brain) using a 10 % SDS PAGE gel and JNK1 antibody at a dilution of 1:1000

Specifications

Host Rabbit
Isotype IgG
Method of Purification JNK1 antibody was purified by antigen-affinity chromatography
Molecular Weight 48 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 0.4 mg/ml

Usage & Assay Information

Usage Recommendations IF:1:100-1:1000, ICC:1:100-1:1000, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

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Images

  • <div><font face=Calibri size=2>Western blot analysis using JNK1 antibody (70R-12562)</font></div>     | Western blot analysis of 50 ug of whole cell lysate (A: Mouse brain) using a 10 % SDS PAGE gel and JNK1 antibody at a dilution of 1:1000
  • <div><font face=Calibri size=2>Immunofluorescent staining using JNK1 antibody (70R-12562)</font></div>     | Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using JNK1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with (Red) at 1:2000.
  • <div><font face=Calibri size=2>Western blot analysis using JNK1 antibody (70R-12562)</font></div>     | Western blot analysis of 30 ug of whole cell lysate (A: Raji) using a 10 % SDS PAGE gel and JNK1 antibody at a dilution of 1:1000

Availability: In stock

Price: €323.11
Size: 100 ul
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