JNK1 antibody (70R-12562)
Affinity purified Rabbit polyclonal JNK1 antibody
Overview
Overview
| Synonyms | Polyclonal JNK1 antibody, Anti-JNK1 antibody, JNK21B1/2 antibody, SAPK1 antibody, c-Jun N-terminal kinase 1 antibody, JNK1, JUN N-terminal kinase antibody, JNK-1 antibody, mitogen-activated protein kinase 8 isoform JNK1 alpha1 antibody, MAP kinase 8 antibody, PRKM8 antibody, JNK 1, JNK antibody, JNK-1, mitogen-activated protein kinase 8 isoform JNK1 beta2 antibody, JNK1 antibody, stress-activated protein kinase 1c antibody, stress-activated protein kinase 1 antibody, JNK1A2 antibody, JNK 1 antibody, MAPK8 antibody, mitogen-activated protein kinase 8 antibody |
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| Cross Reactivity | Human, Mouse |
| Applications | ICC, IF, WB |
| Immunogen | JNK1 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 5 and 300 of JNK1 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | JNK1 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 48 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.4 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:1000, ICC:1:100-1:1000, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. |
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