Karyopherin alpha 2 antibody (70R-12987)
Affinity purified Rabbit polyclonal Karyopherin alpha 2 antibody
Overview
Overview
| Synonyms | Polyclonal Karyopherin alpha 2 antibody, Anti-Karyopherin alpha 2 antibody, QIP2 antibody, Karyopherin alpha -2, RAG cohort 1 antibody, IPOA1 antibody, pendulin antibody, KPNA2 antibody, SRP1alpha antibody, importin-alpha-P1 antibody, karyopherin subunit alpha-2 antibody, RAG cohort protein 1 antibody, Karyopherin alpha 2, Karyopherin alpha 2, Karyopherin alpha 2 antibody, SRP1-alpha antibody, Karyopherin alpha -2 antibody, RCH1 antibody, importin alpha 1 antibody, importin subunit alpha-2 antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, WB |
| Immunogen | Karyopherin alpha 2 antibody was raised in rabbit using a synthetic peptide corresponding to a region within amino acids 468 and 529 of karyopherin alpha 2 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Karyopherin alpha 2 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 58 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.71 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:200, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. |
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