KRAS protein (His tag) (80R-1372)
Purified recombinant Human KRAS protein
|Synonyms||GTPase Kras protein, , C-K-RAS protein, NS3 protein, RASK2 protein, K RAS4B protein, KRAS1 protein, K-RAS4A protein, K-RAS2A protein, K-RAS4B protein, NS 3 protein, K RAS4A protein, K-RAS2B protein, K-RAS2A protein, KRAS 1 protein, KI-RAS protein, K RAS2B protein, KI RAS protein|
Coomassie Blue stained SDS-PAGE of KRAS protein (His tag) (80R-1372)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-185 amino acids: MGSSHHHHHH SSGLVPRGSH MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG HEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SKTKC|
|Grade & Purity||> 90% pure|
|Molecular Weight||23.2 kDa (205aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.1M NaCl,1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||KRAS is a member of the small GTPase superfamily. This protein is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Under normal conditions, Ras family members influence cell growth and differentiation events in a subcellular membrane compartmentalization-based signaling system. Oncogenic Ras can deregulate processes that control both cell proliferation and apoptosis. Recombinant human KRAS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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