LIGHT protein (30R-AL011)
Purified recombinant Human LIGHT protein
Overview
Overview
| Synonyms | CD258 protein, Ligand for herpesvirus entry mediator protein, TNF14 protein, TNFSF14 protein, HVEM-L protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of LIGHT protein corresponding to amino acids RLGEMVTRLP DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV. |
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| Expression System | Hi-5 cells |
| Grade & Purity | > 95% pure |
| Molecular Weight | 19.3 kDa |
| Form & Buffer | Supplied as a lyophilized powder. |
Usage & Assay Information
| Bioactivity | Determined by its ability to induce IL-8 secretion in human BEAS-2B cells. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTbetaR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NF kb, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. |
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