Ly108 antibody (PE) (61R-1313)
Mouse monoclonal Ly108 antibody (PE)
Overview
Overview
| Synonyms | Monoclonal Ly108 antibody, Anti-Ly108 antibody, Ly-108, Ly-108 antibody, Ly 108, SLAM Family Receptor antibody, CD antigen CD352 antibody, Lymphocyte antigen 108 antibody, Ly 108 antibody, SLAM F6 antibody, SLAMF6 antibody, Ly108 antibody, Ly108 |
|---|---|
| Specificity | Mouse |
| Applications | FC |
| Assay Information | A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest |
Images
Flow Cytometric analysis using Ly108 antibody (PE) (61R-1313)
Staining of C57Bl/6 splenocytes with CD45R antibody (FITC) and 0.06 ug of Mouse IgG2a K Isotype Control (PE) (left) or 0.06 ug of Ly-108 antibody (PE) (right). Cells in the lymphocyte gate were used for analysis.
Specifications
| Host | Mouse |
|---|---|
| Clone | 13G3-19D |
| Isotype | IgG2a kappa |
| Tag/Conjugate | PE |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
| Concentration | 200 ug/ml |
Usage & Assay Information
| Usage Recommendations | FC: 0.5 ug/test |
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Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The 13G3-19D monoclonal antibody reacts with mouse Ly108, the mouse homologue of human SLAMF6. Mouse Ly108 is also known as NTB-A, and is expressed on NK, T cells, and B cells. Engagement of the Ly108 receptor enhances NK cell activity and expression of IFN-gamma, and contributes to the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. CD4+ T cells from Ly108 knock-out mice exhibit diminished ability to produce IL-4 and defective neutrophil functions.Staining has not revealed any strain differences between C57BL/6 and BALB/c mice. Other strains have not been tested. |
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