Monoclonal Lymphotoxin beta Receptor antibody, Anti-Lymphotoxin beta Receptor antibody, Tumor necrosis factor receptor superfamily member 3 antibody, LTbeta R antibody, Tumor necrosis factor receptor superfamily member 3 antibody, Anti Lymphotoxin beta Receptor antibody, LTbR antibody, LTbeta R antibody, Lymphotoxin beta Receptor antibody, LTbR antibody
Specificity
Mouse
Applications
FC
Assay Information
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest
Store at 2-8 deg C. Do not freeze. Protect from light.
General Information
Biological Significance
The antibody reacts with mouse lymphotoxin-beta receptor. Northern blot analysis of tissues from adult mice showed that expression levels of LTBR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. The tumor necrosis factor receptor-related protein is the human receptor for the heterotrimer of lymphotoxin- alpha and lymphotoxin-beta. This LT- alpha/LT-beta heterotrimer is assumed to take part in immunologic reactions by cell-cell contact, but does not bind to either TNFR1 or TNFR2. LTBR is expressed by day 7 embryos, so it has been speculated that the LT- alpha/LT-beta receptor system may also have some function in early embryogenesis.