Lyn antibody (20R-2920)
Rabbit polyclonal Lyn antibody
Overview
Overview
| Synonyms | Polyclonal Lyn antibody, Anti-Lyn antibody, LYN antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antibody, BOS_13851 antibody, CH73-38P6.3 antibody, EGK_18962 antibody, Hck-2 antibody, JTK8 antibody, lck/Yes-related novel protein tyrosine kinase antibody, lyn-A antibody, lyn protein non-receptor kinase antibody, lyn protein tyrosine kinase antibody, p53Lyn antibody, p56Lyn antibody, RCJMB04_13j17 antibody, RP23-49A12.2 antibody, Tyrosine-protein kinase Lyn antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein antibody, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog antibody |
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| Cross Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Immunogen | Lyn antibody was raised in Rabbit using a synthetic target peptide as the immunogen |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Lyn antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:2000 |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | The intracellular protein kinase Lyn participates both positively and negatively in B cell, mast cell, platelet and myeloid cell signaling. Lyn is the predominantly expressed Src-family kinase in B cells and its positive role is done through phosphorylation of the Igalpha and Igbeta subunits of B cell receptor. Genetic deletion of Lyn results in autoimmunity, renal disease and premature mortality in mice, and generation of hyperactive Lyn results in the same phenotype, revealing the importance of the balance of Lyn signaling. |
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