Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.
General Information
Product Use
Purified polyclonal LYVE1 antibody specific for Human LYVE1 for use in ELISA, Flow Cytometry and Western Blot.
Biological Significance
LYVE1 is a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan and may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE1 also plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS).
Expression
LYVE1 is mainly expressed in endothelial cells lining lymphatic vessels.LYVE1 is mainly localized to the plasma membrane especially in lymphatic vessels.
Implications in Disease
Diseases associated with LYVE1 include kennedy's disease. a debilitating neurodegenerative disorder resulting in muscle cramps and progressive weakness due to degeneration of motor neurons in the brain stem and spinal cord. The condition is associated with mutation of the androgen receptor (AR) gene and is inherited in an X-linked recessive manner. As with many genetic disorders, no cure is known, although research continues, and intestinal lymphangiectasia, a disease which is characterized by lymphatic vessel dilation, chronic diarrhea and loss of proteins such as serum albumin and globulin. It is considered to be a chronic form of protein-losing enteropathy. LYVE1 may also be linked to tumor metastasis.
Sequence Information
LYVE1 is composed of 322 amino acids with a molecular weight of 35213 Da. There is a Signal peptide domain at positions 1-19.
Post-Translational Modifications
LYVE1 is O-glycosylated. Glycosylation occurs at Asn53 and Asn130.