M-CSF protein (30R-AM005)

Purified recombinant Human M-CSF protein

Synonyms CSF-1 protein, MGI-IM protein, Macrophage Colony Stimulating Factor protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of M-CSF protein corresponding to amino acids MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 36.8 kDa
Form & Buffer Lyophilized from Na3PO4 buffer, pH 8.0, with 75mM NaCl. Reconstitute with distilled water to a concentration of 0.1 to 0.5mg/ml.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse M-NSF-60 cells 1 ng/ml, corresponding to a specific activity of approximately 1 x 10^6 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in Mouse systems, but the Mouse molecule exhibits no activity on human cells.

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Availability: In stock

Price: €211.69
Size: 10 ug
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