Aliquot and store at -20 deg C. Avoid repeated freeze/thaw cycles.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
General Information
Biological Significance
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by means of ~300 kDa cation independent mannose 6-phospate receptors (CI-MPR). In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.