MAP2K2 antibody (70R-2006)

Rabbit polyclonal MAP2K2 antibody raised against the N terminal of MAP2K2

Synonyms Polyclonal MAP2K2 antibody, Anti-MAP2K2 antibody, MEK2 antibody, MKK2 antibody, MAPKK2 antibody, MAP 2 antibody, MAP-2 antibody, Mitogen-Activated Protein Kinase 2 antibody, PRKMK2 antibody, MAP 2, MAP-2, MAP2
Specificity MAP2K2 antibody was raised against the N terminal of MAP2K2
Cross Reactivity Human,Mouse,Rat
Applications WB
Immunogen MAP2K2 antibody was raised using the N terminal of MAP2K2 corresponding to a region with amino acids LARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQK
Assay Information MAP2K2 Blocking Peptide, catalog no. 33R-4794, is also available for use as a blocking control in assays to test for specificity of this MAP2K2 antibody

Images

Immunohistochemical staining using MAP2K2 antibody (70R-2006)

MAP2K2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X

Specifications

Host Rabbit
Method of Purification Affinity purified
Molecular Weight 44 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 50ul distilled water for a 1mg/ml concentration of MAP2K2 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

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Images

  • Immunohistochemical staining using MAP2K2 antibody (70R-2006) | MAP2K2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X
  • Western Blot analysis using MAP2K2 antibody (70R-2006) | MAP2K2 antibody (70R-2006) used at 1 ug/ml to detect target protein.
  • Immunohistochemical staining using MAP2K2 antibody (70R-2006) | MAP2K2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X

Availability: In stock

Price: €324.59
Size: 50 ug
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