MCL1 antibody (20R-MR001)
Rabbit polyclonal MCL1 antibody
Overview
Overview
| Synonyms | Polyclonal MCL1 antibody, Anti-MCL1 antibody, MCL 1, BCL2L3 antibody, MCL-1, Bcl 2 related protein EAT/mcl1 antibody, MCL 1 antibody, MCL-1 antibody, MCL1, Induced myeloid leukemia cell differentiation protein Mcl 1 antibody , BCL2 related antibody, EAT antibody, Myeloid Cell Leukemia 1 antibody, Mcl-1 antibody |
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| Cross Reactivity | Dog, human,monkey, pig, rabbit |
| Applications | IHC, IP, WB |
| Immunogen | MCL-1 antibody was raised in rabbit using a synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1 as the immunogen. |
Images
Western Blot analysis using MCL1 antibody (20R-MR001)
Western Blot analysis of cell lysate using MCL1 antibody at 0.5-4 ug/ml ...
Specifications
| Host | Rabbit |
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| Method of Purification | MCL1 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS bufferwith 50% glycerol, pH 7.2, with 1% BSA, and 0.02% NaN3. |
| Concentration | 0.2 mg/ml |
Usage & Assay Information
| Usage Recommendations | IP: 0.5-4 ug/ml, IHC: 10-20 ug/ml, WB: 1 ug/ml |
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Storage & Safety
| Storage | Aliquot and store at -20 deg C for short term storage, -70 deg C for long-term storage. Avoid repeated freeze/thaw cycles. |
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| Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
General Information
| Biological Significance | Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. |
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