MCM4 antibody (70R-1599)

Rabbit polyclonal MCM4 antibody raised against the N terminal of MCM4

Synonyms Polyclonal MCM4 antibody, Anti-MCM4 antibody, MCM 4, MCM-4 antibody, MCM4, MCM 4 antibody, Minichromosome Maintenance Complex Component 4 antibody, MCM-4
Specificity MCM4 antibody was raised against the N terminal of MCM4
Cross Reactivity Human
Applications WB
Immunogen MCM4 antibody was raised using the N terminal of MCM4 corresponding to a region with amino acids SRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSL
Assay Information MCM4 Blocking Peptide, catalog no. 33R-8784, is also available for use as a blocking control in assays to test for specificity of this MCM4 antibody

Images

Western Blot analysis using MCM4 antibody (70R-1599)

MCM4 antibody (70R-1599) used at 2.5 ug/ml to detect target protein.

Specifications

Host Rabbit
Method of Purification Total IgG Protein A purified
Molecular Weight 95 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 100ul distilled water for a 1mg/ml concentration of MCM4 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 2.5 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRkDaC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

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  • Western Blot analysis using MCM4 antibody (70R-1599) | MCM4 antibody (70R-1599) used at 2.5 ug/ml to detect target protein.

Availability: In stock

Price: €258.73
Size: 100 ug
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