MDC67 protein (30R-AM059)
Purified recombinant Human MDC67 protein
Overview
Overview
| Synonyms | MDC 67 protein, CCL22 protein, MDC-67, MDC67, MDC-67 protein, STCP-1 protein, MDC 67, MDC-67 protein, ABCD-1 protein, Macrophage-Derived Chemokine protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of MDC67 protein corresponding to amino acids YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ. |
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| Expression System | E.coli |
| Grade & Purity | > 98% pure |
| Molecular Weight | 8.0 kDa |
| Form & Buffer | Supplied as a lyophilized powder. |
Usage & Assay Information
| Bioactivity | Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. |
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