Methionine Sulfoxide Reductase A antibody (20R-2889)
Rabbit polyclonal Methionine Sulfoxide Reductase A antibody
Overview
Overview
| Synonyms | Polyclonal Methionine Sulfoxide Reductase A antibody, Anti-Methionine Sulfoxide Reductase A antibody, MSRA antibody, methionine sulfoxide reductase A antibody, BOS_8605 antibody, cytosolic methionine-S-sulfoxide reductase antibody, methionine sulphoxide reductase A antibody, mitochondrial peptide methionine sulfoxide reductase antibody, MSR-A antibody, peptide-methionine (S)-S-oxide reductase antibody, Peptide methionine sulfoxide reductase antibody, peptide met (O) reductase antibody, peptide Met(O) reductase antibody, PMSR antibody, protein-methionine-S-oxide reductase antibody |
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| Cross Reactivity | Mouse, Rat |
| Applications | WB |
| Immunogen | Methionine Sulfoxide Reductase A antibody was raised in Rabbit using a recombinant human protein purified from E.coli as the immunogen |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:2000, |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and a1-proteinase-inhibitor (1-3). Recent studies indicate that there is a connection between MsrA and Alzheimer?s disease in mammals. |
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