Methylmalonyl-CoA Mutase protein (80R-4347)
Recombinant Human Methylmalonyl-CoA Mutase protein
Overview
Overview
| Synonyms | Methylmalonyl CoA Mutase protein, Human Methylmalonyl-CoA Mutase protein, Human MUT protein, Methylmalonyl Coenzyme A Mutase protein, Methylmalonyl-CoA isomerase |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | Full length mature protein, with N terminus His tag. Amino acids 33-750: LHQQQPLH PEWAALAKKQ LKGKNPEDLI WHTPEGISIK PLYSKRDTMD LPEELPGVKP FTRGPYPTMY TFRPWTIRQY AGFSTVEESN KFYKDNIKAG QQGLSVAFDL ATHRGYDSDN PRVRGDVGMA GVAIDTVEDT KILFDGIPLE KMSVSMTMNG AVIPVLANFI VTGEEQGVPK EKLTGTIQND ILKEFMVRNT YIFPPEPSMK IIADIFEYTA KHMPKFNSIS ISGYHMQEAG ADAILELAYT LADGLEYSRT GLQAGLTIDE FAPRLSFFWG IGMNFYMEIA KMRAGRRLWA HLIEKMFQPK NSKSLLLRAH CQTSGWSLTE QDPYNNIVRT AIEAMAAVFG GTQSLHTNSF DEALGLPTVK SARIARNTQI IIQEESGIPK VADPWGGSYM MECLTNDVYD AALKLINEIE EMGGMAKAVA EGIPKLRIEE CAARRQARID SGSEVIVGVN KYQLEKEDAV EVLAIDNTSV RNRQIEKLKK IKSSRDQALA ERCLAALTEC AASGDGNILA LAVDASRARC TVGEITDALK KVFGEHKAND RMVSGAYRQE FGESKEITSA IKRVHKFMER EGRRPRLLVA KMGQDGHDRG AKVIATGFAD LGFDVDIGPL FQTPREVAQQ AVDADVHAVG ISTLAAGHKT LVPELIKELN SLGRPDILVM CGGVIPPQDY EFLFEVGVSN VFGPGTRIPK AAVQVLDDIE KCLEKKQQSV |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid inTris-based buffer with 50% glycerol |
Storage & Safety
| Storage | Store in aliquots at -20 deg C. Avoid repeated freeze thaw cycles. |
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General Information
| Biological Significance | The MUT gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. |
|---|---|
| Implications in Disease | Mutations in the MUT have been suggested to lead to various types of methylmalonic aciduria. |
| Database Links | Uniprot No. P22033 |
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