MFAP2 protein (His tag) (80R-2559)
Purified recombinant MFAP2 protein
Overview
Overview
| Synonyms | Microfibrillar-associated protein 2 protein, MFAP-2 protein, MAGP protein, MAGP-1 protein, Microfibrillar-associated protein 2 protein, MFAP 2 protein, MAGP1 protein, MFAP-2, MFAP2, MFAP 2 |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS-PAGE analysis of MFAP2 protein (His tag) (80R-2559)
SDS-PAGE gel analysis of MFAP2 protein (His tag) where the figure is annotated with amount of protein run on the gel.
Specifications
| Residues | 18-183 aa: MGSSHHHHHH SSGLVPRGSH MGSMQGQYDL DPLPPFPDHV QYTHYSDQID NPDYYDYQEV TPRPSEEQFQ FQSQQQVQQE VIPAPTPEPGNAELEPTEPG PLDCREEQYP CTRLYSIHRP CKQCLNEVCF YSLRRVYVIN KEICVRTVCA HEELLRADLC RDKFSKCGVM ASSGLCQSVA ASCARSCGSC |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Molecular Weight | 21.5 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 1M Urea, 20% glycerol |
| Concentration | 0.5 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage, for long term storage aliquot and freeze at -20 deg C or -70 deg C |
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General Information
| Biological Significance | MFAP2 is an O-glycosylated protein secreted to the extracellular space and the extracellular matrix. MFAP2 associates with biglycan and elastin in a ternary complex. It is shown to play a significant role in the support and distensibility of the juxtacanalicular region of these collector channels. It is also reported to inhibit LTB-1 binding to fibrillin-1, stimulate the phosphorylation of Smad2, and thereby mediate the subsequent extracellular deposition of latent TGFbeta. |
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